TissueSafe serves as a safe alternative for formalin in medical institutions due to the known risks associated with formalin exposure, which include significant threats to human health such as gastrointestinal diseases, skin irritations, and respiratory problems. Unlike formalin, which is toxic to humans, this alternative exhibits no negative effects on nucleic acids and proteins, rendering it suitable for histopathological studies. Moreover, the components utilized are non-toxic and inert, while the polymer employed in preparation demonstrates excellent thermal stability. Furthermore, TissueSafe acts as a stable preservative, with some of its ingredients inherently maintain the biochemical constituents without denaturing or altering them. Not only does TissueSafe provide a safe alternative to formalin, but it also offers a sustainable solution by serving as an alternative to energy-consuming ultra-low-temperature storage.